Croatian-Slovenian Symposium on Zeolites 23 CATIONIC SURFACTANTS-MODIFIED NATURAL ZEOLITES: POTENTIAL EXCIPIENTS FOR ANTI-INFLAMMATORY DRUGS
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چکیده
The aim of this study was to prepare and characterize a potential drug support system based on surfactant/zeolite composites for anti-inflammatory drugs. In order to increase the adsorbing capacity the external surface of the natural zeolite clinoptilolite was modified with benzalkonium chloride in the treatments raging from 100% to 300% of the zeolite external cation exchange capacity. Adsorption of diclofenac diethylamine and ibuprofen on the prepared organozeolites from drug solutions (0.05 0.5 mg/ml) in phosphate buffers pH 7.4 was investigated. Drug adsorption on organozeolites showed a nonlinear type of isotherm and maximum adsorption capacities were 53.19 mg/g for diclofenac diethylamine and 20.04 mg/g for ibuprofen. It was shown that the presence of benzalkonium chloride at the zeolite surface improved adsorption of the model drugs.
منابع مشابه
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